Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita–Baylis–Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhos
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https://figshare.com/articles/dataset/Diastereo_and_Enantioselective_3_2_Cycloaddition_Reaction_of_Morita_Baylis_Hillman_Carbonates_of_Isatins_with_i_N_i_Phenylmaleimide_Catalyzed_by_Me_DuPhos/2529268
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A Me-DuPhos-catalyzed efficient asymmetric [3 + 2] cycloaddition reaction between Morita–Baylis–Hillman carbonates of isatins and N-phenylmaleimide has been developed. This reaction constructs three chiral centers in one step to afford spirocyclopentaneoxindoles in good yields (up to 84%) with excellent diastereo- and enantioselectivies (up to 99% ee).
创建时间:
2016-02-21



