HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one

HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one Descriptor: 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one, Wee1-like protein kinase Authors: Musil, D, Lan, R. Deposit date: 2022-11-06 Release date: 2023-05-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression. Acs Med.Chem.Lett., 14, 2023

本数据集为人类WEE1激酶（WEE1 kinase）与抑制剂1-[6-(1-羟基-1-甲基乙基)-吡啶-2-基]-2-(2-甲氧基苯基)-6-[4-(4-甲基哌嗪-1-基)苯氨基]-1,2-二氢吡唑并[3,4-d]嘧啶-3-酮的复合物。描述符：2-(2-甲氧基苯基)-6-[[4-(4-甲基哌嗪-1-基)苯基]氨基]-1-[6-(2-羟基异丙基)吡啶-2-基]吡唑并[3,4-d]嘧啶-3-酮，Wee1样蛋白激酶。作者：Musil, D、Lan, R. 入库日期：2022-11-06 发布日期：2023-05-31 最后修改日期：2024-02-07 实验方法：X射线衍射（1.53 Å）。引用文献：《选择性WEE1抑制剂在体外展现抗肿瘤活性并与骨髓抑制相关》，刊载于《ACS药物化学通讯》（Acs Med.Chem.Lett.）2023年第14卷。