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Base-Promoted N‑Pyridylation of Heteroarenes Using <i>N</i>‑Propargyl Enaminones as Equivalents of Pyridine Scaffolds

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NIAID Data Ecosystem2026-03-08 收录
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N-Pyridylation of various N-heteroarenes, including N-heteroarene-containing peptides, was achieved using N-propargyl enaminones (isolated or generated in situ from propargyl amine and propynones) as masked polysubstituted pyridine cores. This metal-free procedure proceeds under mild reaction conditions and generates 1 equiv of H2O as the sole byproduct.

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2016-02-13
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