Neonatal protection conferred by BP-2b domains vs the full length protein against GBS strain COH1 assessed by active maternal mouse immunization/neonatal pup challenge model.

Groups of female mice received three doses (on days 1, 21, and 35) of either 20 μg antigen or buffer (PBS) combined in aluminium hydroxide formulations. Mice were then mated, and their offspring were challenged with a GBS dose calculated to induce death in 90% of the pups. Protection values were calculated as [(% dead in control—% dead in vaccine)/% dead in control] x100.*P value, by Fisher’s exact test.Neonatal protection conferred by BP-2b domains vs the full length protein against GBS strain COH1 assessed by active maternal mouse immunization/neonatal pup challenge model.