Crystal structure of protein kinase CK2 catalytic subunit in complex with a Dibromo Dihydro Dibenzofuranone derivative

Crystal structure of protein kinase CK2 catalytic subunit in complex with a Dibromo Dihydro Dibenzofuranone derivative Descriptor: (4~{Z})-7,9-bis(bromanyl)-8-oxidanyl-4-(phenylazanylmethylidene)-1,2-dihydrodibenzofuran-3-one, 1,2-ETHANEDIOL, Casein kinase II subunit alpha, ... Authors: Werner, C, Niefind, K, Jose, J. Deposit date: 2023-10-04 Release date: 2024-10-16 Last modified: 2025-01-01 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E- / Z -Isomers. Acs Pharmacol Transl Sci, 7, 2024与二溴二氢二苯并呋喃酮衍生物结合的蛋白激酶CK2（Protein Kinase CK2）催化亚基的晶体结构 描述符：(4Z)-7,9-二溴-8-羟基-4-(苯肼亚甲基)-1,2-二氢二苯并呋喃-3-酮、1,2-乙二醇、酪蛋白激酶II亚基α（Casein Kinase II subunit alpha）…… 作者：Werner C、Niefind K、Jose J。 沉积日期：2023-10-04 发布日期：2024-10-16 最后修改日期：2025-01-01 实验方法：X射线衍射（分辨率2.26 Å） 引用文献：《7,9-二溴二氢二苯并呋喃作为强效酪蛋白激酶2（CK2）抑制剂的发现：E-/Z-异构体的合成、生物学评价及结构研究》，Acs Pharmacol Transl Sci，7卷，2024年