Overactivation of notch1 signaling in uterine epithelium

We show that the overexpression of N1ICD in the epithelium also results in infertility as a consequence of abnormal differentiation between luminal epithelium (LE) and glandular epithelium (GE), including excessive proliferation in LE and increased response to estrogen in GE. These findings provide insight into the effects of Notch signaling on both types of epithelium. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Ctrl-LE, Ctrl-GE, EOEX-LE, E-OEX-GE.