Evidence for toxic CAG trinucleotide repeats contributing to Huntington’s disease though RNA interference. Evidence for toxic CAG trinucleotide repeats contributing to Huntington’s disease though RNA interference
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA832693
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Mutant huntingtin CAG trinucleotide repeat mimetic hairpins are loaded into the RISC and kill cells through RNAi Overall design: NB7 cells were transfected with different HP mimicking two different mHTT variants or CAG control siRNAs. Subsequently, Ago protein associated short RNAs were pulled down using a GW182 peptide and subjected to smRNA Seq
创建时间：
2022-04-27
