A microglia clonal inflammatory disorder in Alzheimer’s Disease
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2025-03-19
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β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
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Innate immune signaling by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease
Z-DNA is a non-canonical structure capable of activating innate immune signaling through Z-DNA-binding protein 1 (ZBP1). However, the functional significance of ZBP1-mediated detection of Z-DNA in Alz
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Single nucleus RNA sequencing of the cortex of antibiotic and vehicle treated APPPS1-21 mice
Previously, we and others have shown that broad spectrum antibiotic treatment from postnatal day 14-21 reduces neuroinflammation in the APPPS1-21 model of AD-related amyloidosis. In the current study,
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