In vivo CRISPR screening unveils multiple epigenetic regulators as novel tumour suppressor genes in lung cancer. Mus musculus

This study provides the first systematic CRIPSR screening of tumour suppressor genes (TSGs) in vivo and identifies bona fide TSGs especially for epigenetic regulators contributing to lung tumour progression. Moreover, our data provides a potential therapeutic strategy for the effective treatment of UTX-mutant lung tumours. Overall design: mRNA profiles of Kras and Kras/Utx tumors were generated by next generation sequencing