Selected CLRs, their microbial ligands, and the microbes that have altered ability to infect in the absence of the receptor within mice and humans.

A selection of CLRs are listed with identified microbial ligands and phenotypes observed with different pathogens in both mice and humans, where ↑ denotes enhanced susceptibility of the host and ↓ denotes enhanced resistance.*DC-SIGN is a human molecule with related homologues in the mouse; mouse phenotypes described are for SIGNR3 knockouts.**Exact ligand on DV is unknown.***These experiments were performed using blocking antibodies to CLEC5A. Abbreviations: HIV, human immunodeficiency virus; ManLAM, mannosylated lipoarabinomannan; TDM, trehalose-6, 6′-dimycolate.