QTDT association results for individual IL13 SNPs with tIgE levels and Schistosoma mansoni egg count.

Abbreviations: Dir, direction of association; pos, positive; neg, negative; N offspring, number of informative offspring over number of offspring evaluated; neg., negative; pos., positive; QTDT, quantitative transmission disequilibrium test; S.m. count, Schistosoma mansoni egg count per gram of fecal matter; SNP, single-nucleotide polymorphism; tIgE, total serum IgE.alog(10)-transformed values adjusted for age, sex, smoking, and helminthic infection status.blog(10)-transformed values adjusted for age, sex, and low, medium and high exposure to infested water sources.cLikelihood ratio tests were compared to obtain tests of evidence of association in the presence of linkage for models where (1) means were considered as composed of covariate effects and between- and within-family components and (2) means were considered as composed of covariate effects and between-family components only. For both models, the variance was set to be composed of polygenic and individual environmental effects.dP-values are statistically significant with α = 0.05 for atopy-related SNPs (bold) and α = 0.005 for tagging SNPs that are not atopy-related (unbolded).