Figure S1 - Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain

Reduced forebrain 5-HIAA / 5-HT ratio in mice treated with CIT. 5-HIAA / 5-HT ratio in the forebrains of mice treated chronically with CIT or vehicle. 5-HIAA / 5-HT ratio content was significantly lower in mice treated with CIT for 2 days (*p<0.001, Bonferroni post-ANOVA test) or 2 weeks (**p<0.01) but not 4 weeks (p>0.05). Numbers of mice : 2-day CIT-treated, n = 8; 2-day SAL-treated, n = 8; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 9; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 7.
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