Mn(II)-Based MRI Contrast Agent Candidate for Vascular Imaging
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https://figshare.com/articles/dataset/Mn_II_-Based_MRI_Contrast_Agent_Candidate_for_Vascular_Imaging/12350549
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资源简介：
Toxicity
concerns related to Gd(III)-based magnetic resonance imaging
(MRI) agents prompted an intensive research toward their replacement
by complexes of essential metal ions, like Mn(II). Here, we report
a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic
stability (log KMnL = 14.86 and pMn=8.35)
and kinetic inertness (t1/2pH=7.4 = 286.2 h) as well as as remarkable relaxivity (r1p = 23.5 mM–1 s–1, 0.49 T, 37 °C) in the presence of human serum albumin, allowing
a significant MRI signal intensity increase in the vasculature even
at low dose (25 μmol/kg) of the complex.
创建时间：
2020-05-06
