Stress-induced obesity causes cognitive function involving in gut microbiota disturbances and impairment of hippocampal neurogenesis

Fecal samples for microbiome analysis were collected after CUMS (4-week) from donor animals whose time spent in the open arms of the EPMT, immobility time in the FST, and sucrose preference were within 1 standard deviation of the mean values for control mice. Shotgun metagenome sequencing was performed to quantitatively assess differences in bacterial species composition between groups, and the data were analyzed using the Penn CHOP Microbiome Program.