Crystal structure of the SucA domain of Mycobacterium smegmatis KGD, second post-decarboxylation intermediate from 2-oxoadipate

Crystal structure of the SucA domain of Mycobacterium smegmatis KGD, second post-decarboxylation intermediate from 2-oxoadipate Descriptor: (5R)-5-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-(2-{[(phosphonatooxy)phosphinato]oxy}ethyl)-1,3-thiazol-3-ium-2-yl}-5-hydroxypentanoate, CALCIUM ION, MAGNESIUM ION, ... Authors: Wagner, T, Barilone, N, Bellinzoni, M, Alzari, P.M. Deposit date: 2012-12-24 Release date: 2013-11-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Dual Conformation of the Post-Decarboxylation Intermediate is Associated with Distinct Enzyme States in Mycobacterial Alpha-Ketoglutarate Decarboxylase (Kgd). Biochem.J., 457, 2014

耻垢分枝杆菌（Mycobacterium smegmatis）KGD的SucA结构域的晶体结构，其对应2-氧代己二酸脱羧后的第二种中间产物。结构配体信息如下：(5R)-5-{3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-4-甲基-5-(2-{[(膦酰氧基)次膦酰基]氧基}乙基)-1,3-噻唑-3-鎓-2-基}-5-羟基戊酸盐、钙离子、镁离子等。作者：Wagner T、Barilone N、Bellinzoni M、Alzari P.M.。提交日期：2012-12-24；发布日期：2013-11-13；最后修改日期：2023-12-20。结构解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3埃（Å）。引用文献：《分枝杆菌α-酮戊二酸脱羧酶（Kgd）中脱羧后中间产物的双重构象对应不同酶状态》，《生物化学期刊（Biochem.J.）》，第457卷，2014年。