Tracking drug action on the cell surface proteome
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https://www.omicsdi.org/dataset/pride/PXD016249
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资源简介：
Endogenous ligands and drugs interact with the cell-surface proteome but hypothesis-free tracking of dynamic remodeling processes at the plasma membrane is challenging. We introduce cell surface thermal proteome profiling for comprehensive characterization of ligand-induced changes in protein abundances and thermal stabilities. We demonstrate drug binding to extracellular receptors, complexes and transporters, discover stimulation-dependent remodeling of T-cell receptor complexes and describe a competition-based approach to measure target engagement of GPCR antagonists.
创建时间：
2020-10-26
