Input files for scUTRquant-figures repository

OverviewThis dataset contains input and intermediate objects that are part of the minimum dataset required for verifying the analysis reported in Fansler et al., Nat Commun., 2024. These objects are used in the following repositories to generate figures in the manuscript:https://github.com/Mayrlab/scUTRquant-figureshttps://github.com/Mayrlab/hcl-analysishttps://github.com/Mayrlab/mca-analysishttps://github.com/Mayrlab/gwps-sqThe repositories contain additional information on the derivation of the objects.DescriptionsThe folders contain the following data:aparent2 - scores from analyzing human Microwell-seq cleavage sitesbam - genomic alignments of single-cell data subsetted to the 3' cleavage site of Vamp2 in mousebed - cleavage site annotations from hcl-utrome and mca-utrome; reprocessed counts from polyASite 2.0celltype_score - tabulation of number of cell types in which a cleavage site is detectedclusters - APA regulator cluster information derived from Perturb-seq dataconservation - phastCons scores for cleavage site neighborhoodscounts - a note for where to get data from 10X Genomicsdge - results from differential gene expression testingdtu - results from differential transcript usage testing (uses scUTRboot)dwui - results from differential WUI testing in Perturb-seqgtf - annotations of human and mouse UTRomehalflife - isoform-resolved mRNA halflives from K562 SLAM-seq datakallisto - counts and kallisto indices for the UTRomeslui - longest 3'UTR isoform usage point estimates and cell counts in large survey of scRNA-seq datasetsseq - extracted sequences used as input to APARENT2tpm - TPMs and counts per cell (CPC) for mouse and human summarized to cell type; also TPM tables for summarized Perturb-seq datawui - Weighted UTR Index quantifications for all perturbations in K562 and RPE1 essential Perturb-seq screens