LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria Descriptor: (2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((4-((4-((S)-2-hydroxy-1-methoxyethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION Authors: Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. Deposit date: 2021-10-13 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.39 Å) Cite: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published

以氟脯氨酸作为新型锌结合基团的LpxC抑制剂：可作为一类针对多重耐药革兰氏阴性菌的新型抗生素
描述符：(2S,4S)-N-((3R,5R)-1-(环丙甲酰基)-5-((4-((4-((S)-2-羟基-1-甲氧基乙基)苯基)乙炔基)苯甲酰胺基)甲基)吡咯烷-3-基)-4-氟吡咯烷-2-甲酰胺，UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase），锌离子（ZINC ION）
作者：Ryan, M.D、Pallin, T.D、Lamers, M.B.A.C、Leonard, P.M.
存储日期：2021-10-13
发布日期：2022-11-23
最后修改日期：2024-01-31
实验方法：X射线衍射（2.39埃）
引用文献：以氟脯氨酸作为新型锌结合基团的LpxC抑制剂：可作为一类针对多重耐药革兰氏阴性菌的新型抗生素（待发表）