PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD through suppressing eEF2 phosphorylation. Shen et al.

Translation elongation controls the efficiency and accuracy of protein synthesis. Shen et al. discover that the intellectual disability-associated protein PQBP1 regulates translation elongation through direct interaction with eEF2, protecting it from phosphorylation. Loss of PQBP1 in the hippocampal neurons impairs metabotric glutamate receptor-induced long term depression and associated behaviors.翻译延伸（Translation elongation）调控蛋白质合成的效率与准确性。Shen等学者研究发现，与智力障碍相关的蛋白PQBP1可通过与eEF2直接相互作用调控翻译延伸，使其免受磷酸化修饰。在海马神经元中缺失PQBP1会损伤代谢型谷氨酸受体诱导的长时程抑制及其相关行为。