Data supplement.pdf

Figure S1. Relationship between cardiovascular function and cerebrovascular function and brain morphology. Relationship between pulse wave velocity (PWV; a-d-f), brachial flow-mediated dilation (FMD; b-e-g), and carotid intima media thickness (IMT; c-f-h) with cerebral blood flow (CBF0; a-c), cerebrovascular reactivity in response to a breath hold (CVRBH d-f), and normalized gray matter volume (GMV; f-h) in young (filled circles) and old adults (filled squares; n=12-14 per group). Individual dots reflect individual data points and the dotted line around the line of best fit represents 95% confidence intervals for the grouped data.The study protocol was approved by the Queen’s University Health Sciences Research Ethics Board (#6020830; Kingston, ON, Canada).