Metabolite lists differentiating OB from OB/D subjects at each time point.

Metabolites were identified using a mixed-effects ANOVA: 33 metabolites at T0, 32 metabolites at T3, and 28 metabolites at T6 (p<0.05), with indication of whether serum levels are higher in obese (OB) or obese/diabetic (OB/D) subjects. Those metabolites present in all three lists are indicated in bold font. The profiles for metabolites whose abundance changed post surgery are found in FIGURE 1. (*1): Structure annotation is based on strong analytical evidence (combinations of chromatography, mass spectrometry, chemical reactions, deuterium-labeling, database and literature search, as well as comparisons to similar/homologue/isomeric reference compounds). (*2): Metabolite exhibits identical qualitative analytical characteristics (chromatography and mass spectrometry) compared to status (*1). Further structural and analytical investigations of this metabolite - also in comparison to structurally identified or status (*1) metabolites - are still pending.