Construction of Spirocyclopropane-Linked Heterocycles Containing Both Pyrazolones and Oxindoles through Michael/Alkylation Cascade Reactions
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https://figshare.com/articles/dataset/Construction_of_Spirocyclopropane_Linked_Heterocycles_Containing_Both_Pyrazolones_and_Oxindoles_through_Michael_Alkylation_Cascade_Reactions/2106682
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资源简介：
An effective diastereoselective Michael/alkylation
cascade reaction of arylidenepyrazolones with 3-chlorooxindoles catalyzed
by DIPEA was developed. A variety of highly functionalized spiro-pyrazolone-cyclopropane-oxindoles
were obtained in excellent yields (up to 99%) with good to excellent
diastereoselectivities (up to >25:1 dr). Moreover, the squaramide-catalyzed
asymmetric reactions of arylidenepyrazolones with 3-chlorooxindoles
afforded the corresponding chiral spirocyclic heterocycles in excellent
yields (up to 99%) with moderate diastereoselectivities (up to 87:13
dr) and moderate to high enantioselectivities (up to 74% ee).
创建时间：
2016-02-12
