Immune signatures predict development of autoimmune toxicity in immune checkpoint inhibitor-treated patients with cancer

<strong>Immune signatures predict development of autoimmune toxicity in immune</strong><strong> checkpoint inhibitor-treated patients with cancer</strong> Nicolas Gonzalo Nuñez¹*, Fiamma Berner²*, Ekaterina Friebel¹*, Susanne Unger¹, Nina Wyss^2,3, Julia Martinez Gomez⁴, Mette-Triin Purde², Rebekka Niederer^2,3, Maximilian Porsch⁵, Christa Lichtensteiger², Rafaela Kramer⁶, Michael Erdmann⁶, Christina Schmitt⁷, Lucy Heinzerling^6,7, Marie-Therese Abdou², Julia Karbach⁸, Dirk Schadendorf⁹, Lisa Zimmer⁹, Selma Ugurel⁹, Niklas Klümper^10,11,12, Michael Hölzel^10,11, Laura Power¹, Stefanie Kreutmair¹, Mariaelena Capone¹³, Gabriele Madonna¹³, Lacin Cevhertas^14,15, Anja Heider¹⁴, Teresa Amaral^16,17, Omar Hasan Ali^2,3,4,18, David Bomze^2,19, Florentia Dimitriou⁴, Stefan Diem²⁰, Paolo Antonio Ascierto¹³, Reinhard Dummer⁴, Elke Jäger⁸, Christoph Driessen²⁰, Mitchell P. Levesque⁴, Willem van de Veen¹⁴, Markus Joerger²⁰, Martin Früh^20,21, Burkhard Becher¹**, Lukas Flatz^2,3,4,20,22** */** these authors contributed equally Affiliations 1. Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland 2. Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, St.Gallen, Switzerland 3. Department of Dermatology, Kantonsspital St. Gallen, St.Gallen, Switzerland 4. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland 5. Department of Radiology, Kantonsspital St. Gallen, St.Gallen, Switzerland 6. Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany 7. Ludwig Maximilian University of Munich, Munich, Germany 8. Department of Oncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany 9. Department of Dermatology, Comprehensive Cancer Center (Westdeutsches Tumorzentrum) University Hospital Essen, Essen, Germany 10. Institute for Experimental Oncology, University Hospital Bonn, Bonn, Germany 11. Center for Integrated Oncology Cologne/Bonn, University Hospital Bonn, Bonn, Germany 12. Department of Urology, University Hospital Bonn, Bonn, Germany 13. Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Napoli, Italy 14. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland 15. Department of Medical Immunology, Institute of Health Sciences, Bursa Uludag University, Bursa, Turkey 16. Skin Cancer Center, Department of Dermatology, University Hospital Tübingen, Tübingen, Germany 17. iFIT Cluster of Excellence (EXC 2180), University of Tübingen, Tübingen, Germany 18. Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada 19. Sackler Faculty of Medicine, Tel-Aviv University, Israel 20. Department of Oncology, Kantonsspital St. Gallen, St.Gallen, Switzerland 21. Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 22. Universitäts-Hautklinik, University of Tübingen, Tübingen, Germany