Dataset for: The influence of an environmentally relevant polychlorinated biphenyl mixture on the intestinal microbiota in post-weaning mouse dams.

This dataset comprises data from a study examining the effect of maternal exposure to a human-relevant PCB mixture, known as the MARBLES mix, on the gut microbiome of pregnant female mice. Female C57BL/6J mice were dosed daily with the MARBLES mix at varying concentrations (0, 0.1, 1, or 6 mg/kg body weight/day) before mating and throughout gestation and lactation. Intestinal contents were collected to characterize the microbiome composition and predict its function using 16S rRNA sequencing. Additionally, the quantification of PCBs and their metabolites was performed using gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatography-high resolution mass spectrometry (LC-HRMS). An interactive network analysis was conducted to identify associations between specific PCBs and metabolites and changes in bacterial abundance.