Body weights following CORT, stress, and 7,8-DHF.

(Row A). The change in body weight across days of mice exposed to CORT or water during early adolescence depended on CORT status (day × CORT interaction F(5,75) = 4.1, p = 0.003), but post hoc tests were nonsignificant. (Row B) In adult mice, body weight change across days also depended on CORT status (day × CORT interaction F(5,60) = 12.1, p < 0.001), but post hoc tests were nonsignificant. (Row C) Body weight of mice exposed to repeated forced swimming or control manipulation during early adolescence increased across days (main effect of day F(5,65) = 22.7, p < 0.001), with no group differences (main effect and interaction p > 0.05). (Row D) For mice exposed to CORT or water during adolescence and treated with 7,8-DHF (0.0, 3.0, or 10.0 mg/kg), the change in body weight across days depended on CORT status (day × CORT interaction F(8,240) = 18.1, p < 0.001], with CORT impairing normal weight gain (days on which control and CORT groups significantly differed are indicated by asterisks, as determined by post hoc tests). There were no effects of 7,8-DHF treatment alone, nor any interactions (p > 0.05). (Row E) The average body weight of female mice exposed to CORT or water during early adolescence and treated with 0.0 or 3.0 mg/kg of 7,8-DHF increased across days (main effect F(8,168) = 42.1, p < 0.001), with no group differences (p > 0.05). Shaded cells indicate the period of 7,8-DHF or vehicle administration. Unit of measure is grams. ** refers to interaction effects; * refers to post hoc comparisons (both p < 0.05). 7,8-DHF dosing (in mg/kg) is indicated in parentheses. Raw data for this table can be found in S1 Data.