Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A272

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A272 Descriptor: 2-ethyl-2-methanoyl-~{N}-[3-[[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide, CHLORIDE ION, Dipeptidyl peptidase 8, ... Authors: Ross, B.H, Huber, R. Deposit date: 2020-08-18 Release date: 2021-06-30 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 2022与基于4-氧代-β-内酰胺的抑制剂A272结合的二肽基肽酶8晶体结构 描述符：2-乙基-2-甲酰基-N-[3-[[4-(萘-1-基甲基)哌嗪-1-基]甲基]苯基]丁酰胺、氯离子、二肽基肽酶8…… 作者：Ross, B.H、Huber, R. 沉积日期：2020-08-18 发布日期：2021-06-30 最后修改日期：2024-11-13 实验方法：X射线衍射（分辨率3 Å） 引用文献：通过化学蛋白质组学技术鉴定4-氧代-β-内酰胺类化合物为二肽基肽酶8和9的抑制剂，《Angew.Chem.Int.Ed.Engl.》，2022年