THSD7A
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The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]
该基因编码的蛋白质几乎仅存在于胎盘和脐带内皮细胞中。该编码的蛋白质似乎与α(V)β(3)整合素和paxillin相互作用,以抑制内皮细胞的迁移和管状结构形成。该蛋白质可能参与细胞骨架的构建。该基因的变异可能与骨质疏松症中的低骨矿物质密度有关。[资料来源:RefSeq,2010年8月]
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