Supporting data for 'Medical Devices-Assisted Nanomedicine for Cancer Therapy'

This dataset contains original data of the three research projects in my PhD thesis 'Medical Devices-Assisted Nanomedicine for Cancer Therapy'. In the first project, a biomimetic nanoparticle-loaded injectable thermosensitive hydrogel (RPE-PF127) was fabricated for targeted delivery of the chemotherapeutic agent etoposide to retinoblastoma. The biomimetic nanoparticles, RPE NPs, were formed by coating etoposide-loaded PLGA nanoparticles with WERI-Rb-1 cell membranes. The RPE NPs were uniformly dispersed in the thermosensitive PF127 solution and intravitreally injected for retinoblastoma treatment. The PF127 matrix enabled longer intraocular retention of the RPE NPs, while the WERI-Rb-1 cell membrane coating facilitated targeted delivery and enhanced antitumor efficacy in an orthotopic retinoblastoma-bearing mouse model.In the second project, an optical fiber was employed for efficient light delivery to trigger photodynamic therapy. PEG-HeLa NPs were formed by coating pegylated HeLa cell membranes on FDA-approved photosensitizer Chlorin e6 (Ce6)-loaded PLGA nanoparticles, which possessed both mucus-penetrating ability and homotypic tumor-targeting effects. Using optical fiber-guided light irradiation, PEG-HeLa NPs demonstrated outstanding local retention and antitumor efficacy following intravaginal injection in an orthotopic cervicovaginal tumor-bearing mouse model.In the third project, a PDMS film-sealed, wirelessly powered LED served as a light source for photodynamic immunotherapy in postsurgical care. The sealed LED was implanted locally after the tumor removal. Concurrently, photocleavable building blocks (BODIPY)3-tris(2-aminoethyl)amine (BTAEA), immunomodulator NLG919, and the amphiphilic lipid polymer DSPE-mPEG were co-assembled into nanoparticles (NBTNPs). Under light irradiation at 527 nm with low irradiance over an extended period, the implanted wireless LED triggered disassembly of NBTNPs, releasing NLG919. This process significantly inhibited primary tumor recurrence and distant tumor growth by activating the immune response. No noticeable side effects or tissue burning were observed during treatment.