Evaluation of the p53 isoform Δ133p53β aggregation capacity

p53 isoforms and particularly Δ133p53β play a critical role in cancer progression. We demonstrate that WT Δ133p53β activity is regulated through an aggregation-dependent mechanism. Creation of WT Δ133p53β aggregates depends on associations with specific interacting partners and was observed both in cancer cell lines and in human tumour biopsies.