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Bromodomain targeting overcomes treatment resistance in distinct molecular subtypes of melanoma

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NIAID Data Ecosystem2026-03-13 收录
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NSG mice bearing tumors from the MM-300 PDX line were treated with vehicle or the combination of bromosporine + cobimetinib (bromo+cobi) NSG mice bearing tumors from the MM-300 PDX line were treated with vehicle or the combination of bromosporine + cobimetinib (bromo+cobi). RNA was extracted from subcutaneous tumors to perform next generation sequencing to identify differentially expressed genes between the vehicle and drug treatment groups. RNA Seq was performed from tumors of 3 mice each for vehicle vs. treatment group.

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2022-08-31
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