D-amino acids control IgA production. DAA-IgA
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB35803
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资源简介：
Intestinal microbiota produces D-amino acids, which are bacteria-specific metabolites, for their growth and their communication. Host intestine release D-amino acid oxidase (DAO) to degrade bacterial D-amino acids that results in regulation of microbiota. However, it is not clarified whether bacterial D-amino acids affect host’s immunity. In the present study, we compared microbiota in DAO null mice with that of wild type. 16S metagenomic sequence revealed growth of specific bacteria, which promote IgA production, in DAO null mice. This result indicates that DAO inhibit IgA production through prevention of growth of IgA-inducible bacteria.
创建时间：
2020-08-31
