Inhibition or genetic deletion of poly(ADP-ribose) polymerase-1 (PARP-1) is profoundly protective against a number of toxic insults in many organ systems1,2. In the brain the molecular mechanisms unde
Source data for Casterton et al. 2026 Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress. Supplementary Figure 2 and Figure 3 - part 2
BackgroundIntestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue
