CD5+ B-1a cells is a dominant population of innate-like B cells that play critical roles in innate defense and immune regulation. In our model, mTORC1 enhances B-1a cells development and differentiati

NIAID Data Ecosystem10

scRNA-seq time course of B cell differentiation in organoid cultures

B细胞分化

单细胞转录组学

To understand how different stimulation conditions impacted the maturation of B cells and formation of plasma cells in an ex vivo organoid culture, we preformed 10X single-cell RNA-seq comparing the C

NIAID Data Ecosystem10

Data_Sheet_1_RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion.PDF

B细胞分化

疫苗开发

Secondary plasma cells (PCs) originate from memory B cells and produce increased levels of antibodies with higher affinity compared to PCs generated during primary responses. Here we demonstrate that

NIAID Data Ecosystem30

Table_3_A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.xlsx

B细胞分化

CRISPR-Cas9

IntroductionThe differentiation of B cells into antibody-secreting plasma cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood. MethodsWe ha

NIAID Data Ecosystem10

Early B-cell Differentiation is Coupled to Targeted DNA Hypomethylation. Mus Musculus

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