KRAS G13D Mutant in Complex with GDP and Compound 6.

KRAS G13D Mutant in Complex with GDP and Compound 6. Descriptor: (3R)-1-[(7P)-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-7-(3-hydroxynaphthalen-1-yl)pyrido[4,3-d]pyrimidin-4-yl]piperidin-3-ol, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... Authors: DiDonato, M, Spraggon, G. Deposit date: 2025-12-15 Release date: 2026-06-03 Last modified: 2026-06-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation. J.Med.Chem., 69, 2026