Transcriptomics Dataset of BV2 Microglia cells Following TDP-43 Knockdown and Non-Silencing Control

In this study, we investigate how knockdown of the RNA-binding protein TDP-43 alters the transcriptional program of BV2 microglial cells. Aberrant TDP-43 function is a hallmark of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and while most research has focused on neurons, emerging evidence points to a critical role for microglia in modulating neuroinflammation and disease progression. We employed RNA interference to specifically deplete TDP-43 in BV2 cells (TDP-43 RNAi) and compared them to cells treated with a non-silencing control siRNA. <br>Raw reads and protocol details can be found in ArrayExpress with Accession: <b>E-MTAB-15184</b><br>Study type: Bulk RNA-seq of coding RNA<br>Organism: Mus musculus<br>