Structure of neuronal nitric oxide synthase heme domain in complex with N,N'-([1,1'-biphenyl]-3,3'-diyl)bis(thiophene-2-carboximidamide)

Structure of neuronal nitric oxide synthase heme domain in complex with N,N'-([1,1'-biphenyl]-3,3'-diyl)bis(thiophene-2-carboximidamide) Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N,N'-biphenyl-3,3'-diyldithiophene-2-carboximidamide, ... Authors: Li, H, Poulos, T.L. Deposit date: 2013-04-24 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J.Med.Chem., 57, 2014

与N,N'-([1,1'-联苯]-3,3'-二基)双(噻吩-2-甲脒)结合的神经元型一氧化氮合酶（neuronal nitric oxide synthase）血红素结构域的晶体结构。组成组分：5,6,7,8-四氢生物蝶呤、乙酸根离子、N,N'-联苯-3,3'-二基二噻吩-2-甲脒…… 作者：Li, H、Poulos, T.L.。沉积日期：2013-04-24，发布日期：2014-02-12，最后修改日期：2023-09-20。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.15埃）。引用文献：《强效选择性双头噻吩-2-甲脒类神经元型一氧化氮合酶抑制剂用于黑色素瘤治疗》，《药物化学杂志》，57卷，2014年。