Changes of Hippocampal Protein Levels during Postnatal Brain Development in the Rat

Information on postnatal brain protein expression
is very limited, and we therefore compared hippocampal
protein levels in rat hippocampus at different developmental time points using two-dimensional gel electrophoresis followed by mass spectrometrical protein identification and specific software for quantification. Proteins
from several cascades as e.g., antioxidant, metabolic,
cytoskeleton, proteasomal, and chaperone pathways were
developmentally regulated, which is relevant for design
and interpretation of protein chemical studies in the
mammalian brain.
Keywords: temporal regulation • rat • hippocampus • postnatal
development • MALDI • brain development • age-dependent
protein expression