The Cancer Genome Atlas Low Grade Glioma Collection (TCGA-LGG)

The Cancer Genome Atlas Low Grade Glioma (TCGA-LGG) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.癌症基因组图谱低级别胶质瘤（The Cancer Genome Atlas Low Grade Glioma, TCGA-LGG）数据集集合作为一项更大规模研究计划的组成部分，其核心目标是构建连接癌症表型与基因型的研究共同体，具体实现路径为：为癌症基因组图谱（The Cancer Genome Atlas, TCGA）的受试者匹配对应的临床影像。临床、遗传与病理数据存储于基因组数据通用库（Genomic Data Commons, GDC）数据门户，而放射影像数据则存放于癌症影像档案（The Cancer Imaging Archive, TCIA）。匹配的TCGA患者标识符可帮助研究人员检索TCGA与TCIA数据库，以探究组织基因型、放射影像表型与患者预后之间的关联。TCGA的组织样本采自全球各地的多家机构，以达成每种癌症类型约500份标本的入组目标。正因如此，该影像数据集在扫描模态、设备厂商与采集协议方面均存在高度异质性。在多数情况下，影像采集属于常规诊疗流程的一部分，而非受控研究或临床试验的组成部分。

搜集汇总

背景与挑战

背景概述

TCGA-LGG数据集是癌症基因组图谱低级别胶质瘤数据收集的一部分，旨在通过匹配临床影像与TCGA受试者，连接癌症表型与基因型。数据分为两部分：临床、遗传和病理数据存储在GDC Data Portal，放射学数据存储在TCIA，支持研究人员探索基因型、表型与患者结果的相关性。数据来源全球多站点，导致图像数据在扫描设备和协议上高度异质，且主要来自常规护理而非受控研究。