To visualize whether HiLands-P chromatin is decondensed, we used Oligopaint method -a modified fluorescence in situ hybridisation (FISH) technique specifically for imaging large Chromatic loci-to quan
A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate and respond to stimuli and for identifying the causes of diseases. Chromatin remo
The nuclear lamina can bind and sequester transcription factors (TFs), a function lost if the lamina is abnormal, with missing or mutant lamin proteins. We now show that TF sequestration is not all-or