Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine

Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ... Authors: Qiao, Q, Wang, M, Xu, R.M. Deposit date: 2010-08-31 Release date: 2010-12-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation J.Biol.Chem., 286, 2010

人类组蛋白赖氨酸N-甲基转移酶NSD1的SET结构域与S-腺苷-L-甲硫氨酸（S-adenosyl-L-methionine）复合物的晶体结构。数据集描述：该蛋白为组蛋白赖氨酸N-甲基转移酶，特异性催化H3赖氨酸36位与H4赖氨酸20位的甲基化修饰，配体包含S-腺苷-L-甲硫氨酸等。作者：Qiao Q、Wang M、Xu R.M. 存档日期：2010-08-31；发布日期：2010-12-22；最后修改日期：2024-03-20；实验方法：X射线衍射（1.75埃）；引用文献：NSD1的晶体结构揭示了组蛋白H3K36甲基化的自主调控机制，发表于《J. Biol. Chem.》2010年第286卷。