Gene expression profile at single cell level of isogenic iPSC-derived primitive erythroblasts (RBCs), iPSC-derived definitive RBCs and Fetal liver-derived RBCs

In this study, we generated and validated in vitro models to study human embryonic and fetal erythropoiesis using induced pluripotent stem cells (iPSCs). We used distinct differentiation protocols to generate pure embryonic or fetal RBCs from iPSCs and compared them with genetically matched isogenic erythroid cells from a primary fetal liver