Genome-wide maps of chromatin state in thymocytes from Nsd2-edited mice

We performed high-throughput profiling of histone modifications in mouse thymocytes in which Nsd2 were deleted (KO) or Nsd2 were substituted as following c.2717C>T; p.Pro906Leu that is an orthologous substitution of human NSD2 c.2714C>T; p.Pro905Leu (KI). We found that lysine 36 dimethylation were generally decreased in KO and KI. These were associated with regulation of gene expression. Overall design: Examination of histone H3 lysine 36 dimethylation in mice thymocytes.