DNA-damage induced differentiation of leukemic cells as an anti-cancer barrier
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https://www.ncbi.nlm.nih.gov/sra/SRP041515
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资源简介：
Here we show that the histone methyltransferase MLL4 (Kmt2d) is required for stem cell activity and an aggressive form of acute myeloid leukemia (AML) harboring the MLL-AF9 oncogene. MLL4 exerts its function by regulating transcriptional programs associated with the anti-oxidant response. Overall design: The role of Mll4 (Kmt2d) in regulating the transcriptome of primary and transformed hematopoietic stem cells was studied.
创建时间：
2017-10-20
