Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with pyruvate bound in the active in C2221 space group

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with pyruvate bound in the active in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-02 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.04 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS To Be Published

空肠弯曲菌（C.jejuni）来源的二氢二吡啶甲酸合酶（Dihydrodipicolinate synthase, DHDPS）的Y110F突变体，其活性位点结合丙酮酸，以空间群C222₁结晶。本数据集的描述内容包括：1,2-乙二醇（1,2-ETHANEDIOL）、4-羟基四氢二吡啶甲酸合酶（4-hydroxy-tetrahydrodipicolinate synthase）、乙酸根离子（ACETATE ION）等。作者：Saran S、Sanders D.A.R.。沉积日期：2020-12-02；发布日期：2021-12-08；最后修改日期：2023-11-29。实验方法：X射线衍射（分辨率2.04 Å）。引用说明：B因子分析表明，L-赖氨酸与R,R-二赖氨酸可通过降低蛋白质动力学，变构抑制Cj.DHDPS酶活性，该成果待发表。