Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life

Methionine supplementation during the suckling period of ewe lambs (F0) may modify DNA methylation in the germline (F0) during this critical window period for the neonate, hence promoting inter-generational transmission of epigenetic marks to the offspring (F1). This factor may alter the expression of specific genes and physiological traits throughout life of the offspring (F1). The results of the present study revealed that methionine supplementation during the suckling period of ewe lambs (F0) caused the transmission of epigenetic marks to the offspring (DNA obtained from the blood of 1-month old Assaf ewe lambs, F1), so genes involved in Developmental process and Anatomical structure development were differentially methylated in F1-MET when compared to F1-CTRL ewe lambs. Therefore, although the effects on feed efficiency during adulthood were limited, F1-MET dairy sheep showed a reduced live body weight during the whole life.