Functional assessment of a new PBX1 variant through CRISPR-Cas9 gene editing
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下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP403103
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资源简介：
To assess the role of a variant of unknown significance in PBX1 (p.(Arg107Gln) by generating a HEK293T-derived cell line knockdown for PBX1 (clone 22 cells) through CRISPR-Cas9. We then transfected the KD cells or the WT HEK293T cells with a plasmid encoding either WT or Arg107Gln PBX1 proteins. Overall design: Comparative gene expression profiling analysis of RNA-seq data for WT HEK293T cells and clone 22 cells after transient transfection with plasmid encoding WT PBX1 (WT) or Arg107Gln PBX1 (MUT)
创建时间：
2023-02-28
