Additional file 1 of MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer

Additional file 1: Table S1. Differential expression analysis of MCF7 cell lines following 48 hours treatment with NVP-CGM097 versus vehicle (0.01% DMSO). Table S2: Differential expression analysis of MCF7 cell lines following 48 hours treatment with Fulvestrant versus vehicle (0.01% DMSO). Table S3. Differential expression analysis of MCF7 cell lines following 48 hours treatment with combination therapy (NVP-CGM097 + fulvestrant) versus vehicle (0.01% DMSO). Table S4. Differential genes induced by combination therapy (NVP-CGM097 + fulvestrant) versus vehicle (0.01% DMSO). Table S5. KEGG PATHWAY enrichment analysis of differentially expressed genes following treatment with combination of NVP-CGM097 and fulvestrant versus vehicle (0.01% DMSO). Table S6. Combination effect quantified for all genes following treatment with NVP-CGM097, fulvestrant and combination across cell lines. Table S7. Differential expression analysis of the PDX breast cancer model treated with NVP-CGM097 versus vehicle. Table S8. Differential expression analysis of the PDX breast cancer model treated with fulvestrant versus vehicle. Table S9. Differential expression analysis of the PDX breast cancer model treated with combination therapy versus vehicle. Table S10. Gene set enrichment analysis of DE genes induced by NVP-CGM097 in MCF-7 cell lines. Table S11. Gene set enrichment analysis of DE genes induced by fulvestrant in MCF-7 cell lines. Table S12. Gene set enrichment analysis of DE genes induced by combination therapy in MCF-7 cell lines. Table S13. Gene set enrichment analysis of DE genes induced by NVP-CGM097 in the PDX treated model. Table S14. Gene set enrichment analysis of DE genes induced by fulvestrant in the PDX treated model. Table S15. Gene set enrichment analysis of DE genes induced by combination therapy in the PDX treated model. Table S16. Combination effect quantified for all genes following treatment with NVP-CGM097, fulvestrant and combination in the PDX model. Table S17. Differential expression analysis of MCF7 cell lines following 48 hours treatment with NVP-CGM097 versus vehicle (0.01% DMSO). Table S18. Differential expression analysis of MCF7 cell lines following 48 hours treatment with palbociclib versus vehicle (0.01% DMSO). Table S19. Differential expression analysis of MCF7 cell lines following 48 hours treatment with combination therapy (NVP-CGM097 + palbociclib) versus vehicle (0.01% DMSO). Table S20. Combination effect quantified for all genes following treatment with NVP-CGM097, palbociclib and combination across cell lines.