A. Datasets

The comprehensive list of lncRNAs dysregulated in diverse human cancers, their expression patterns, methodologies of their identification, and references to research articles (PubMed ID) used to gather these details were obtained from the Lnc2Cancer 3.0 dataset. The aliases of all these lncRNAs were manually compiled from the GeneCards dataset. The nucleotide sequences and the corresponding NCBI accession numbers of all the identified lncRNAs, including their functional transcript variants, with “validated” or “reviewed” RefSeq status, were retrieved from NCBI Nucleotide.For identification of Putative Quadruplex-forming Sequences (PQS) within these lncRNAs, their FASTA sequences are imported to the QGRS mapper, a tool that presents data on the constitution and distribution of Quadruplex-forming G-rich sequences (QGRS). The PQS within these lncRNAs are also identified using G4Hunter, a tool for identifying putative G4-forming motifs based on the G-richness and G-skewness of the query sequence.The details of experimentally-validated RNA and protein interacting partners of catalogued lncRNAs were sourced from NPInter v4.0 and LncTarD 2.0 datasets. The data obtained from LncTarD 2.0 was filtered to present the data exclusively in the context of human cancers. The information on the experimentally-validated RNA G4-binding proteins (RGBPs) interacting with the catalogued lncRNAs was obtained from QUADRatlas and G4IPDB datasets, supplemented by scientific literature mining.