Matrix Stiffness-Driven Cytoskeletal Remodeling and Tumor Progression in Anaplastic Thyroid Cancer via Integrin-Focal Adhesion Kinase Signaling

Anaplastic thyroid cancer (ATC) is a highly lethal malignancy characterized by rapid progression and therapeutic resistance. This study uncovers the pivotal role of extracellular matrix (ECM) stiffness in driving ATC aggressiveness through mechanotransduction mediated by the Integrin