Discovery of predictors for the efficiency of porcine Mycoplasma hyopneumoniae vaccine response: 16S rRNA gene fecal microbiota analysis

The gut microbiota comprises a large and diverse community of bacteria that play a significant role in swine health. Indeed, there is a tight association between the enteric immune system and the overall composition and richness of the microbiota, which is key in the induction, training and function of the host immunity and may therefore influence immune response to vaccination. Using vaccination against Mycoplasma hyopneumoniae (M. hyo) as model study, we investigated the potential of early-life gut microbiota in predicting vaccine response and explored the dynamics of fecal microbiota at later time points